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Iowa State's Kane hits game-winning layup with 1.6 seconds left to oust North Carolina 85-83

  • NCAA North Carolina Iowa St Basketball-1.jpg

    North Carolina's J.P. Tokoto (13) shoots over Iowa State's Matt Thomas (21) during the first half of a third-round game in the NCAA college basketball tournament Sunday, March 23, 2014, in San Antonio. (AP Photo/David J. Phillip)The Associated Press

  • NCAA North Carolina Iowa St Basketball-2.jpg

    Iowa State's DeAndre Kane (50) is defended by North Carolina's J.P. Tokoto, left, and Desmond Hubert (14) during the first half of a third-round game in the NCAA college basketball tournament Sunday, March 23, 2014, in San Antonio. (AP Photo/Eric Gay)The Associated Press

  • NCAA North Carolina Iowa St Basketball-3.jpg

    Iowa State's DeAndre Kane (50) shoots over North Carolina's Isaiah Hicks (22) during the first half of a third-round game in the NCAA college basketball tournament Sunday, March 23, 2014, in San Antonio. (AP Photo/Eric Gay)The Associated Press

  • NCAA North Carolina Iowa St Basketball-4.jpg

    Iowa State coach Fred Hoiberg calls to his players during the first half of a third-round game against North Carolina in the NCAA college basketball tournament Sunday, March 23, 2014, in San Antonio. (AP Photo/David J. Phillip)The Associated Press

  • NCAA North Carolina Iowa St Basketball-5.jpg

    North Carolina's Nate Britt, left, and Iowa State's Melvin Ejim (3) chase a loose ball during the first half of a third-round game in the NCAA college basketball tournament Sunday, March 23, 2014, in San Antonio. (AP Photo/David J. Phillip)The Associated Press

DeAndre Kane drove for the game-winning layup with 1.6 seconds left and No. 3 seed Iowa State beat North Carolina 85-83 on Sunday, advancing to the Sweet 16 for the first time since 2000.

The Cyclones (28-7) head to Madison Square Garden next week to face No. 7 seed Connecticut in the East Regional semifinals.

The Tar Heels (24-10) are gone in the NCAA tournament's opening weekend for the first time in consecutive seasons under coach Roy Williams.

North Carolina's Nate Britt raced the ball up court after Kane's basket, but time expired before he could reach halfcourt and call a timeout. Officials huddled for several minutes reviewing clock replays before ruling the game was over.