Jennifer O'Neill scored 21 points, Samarie Walker added 12 with 14 rebounds and third-seeded Kentucky crushed No. 14 Wright State 106-60 on Saturday.
Hosting their first NCAA women's postseason game, the Wildcats (25-8) used home court and other advantages to overwhelm an undersized Raiders squad making their tournament debut. Kentucky shot 55 percent from the field, outrebounded Wright State 49-19 and recorded a season-high 12 blocks.
The Wildcats will face the winner between No. 11 Chattanooga and No. 3 Syracuse in Monday night's second round of the Notre Dame Regional.
Walker had her season's ninth double-double at halftime. The Wildcats achieved their season best in blocks early in the second half.
Janee Thompson added 14 points, Linnae Harper 12, DeNesha Stallworth and Bria Goss 11 each and Aziz Bishop 10 for Kentucky.
Ivory James had 16 points to lead Wright State (26-9).