Tia Gibbs scored 17 points and No. 3 Louisville pulled away from Cincinnati in the second half for a 75-51 victory Saturday.
Antonita Slaughter added 14 points, Asia Taylor finished with 12 and Shoni Schimmel scored 10, helping keep alive Louisville's bid for a share of the inaugural American Athletic Conference championship.
The second-place Cardinals (28-2, 16-1) went into Saturday's game trailing top-ranked and conference-leading Connecticut by one game.
The two are scheduled to meet in the regular-season finale on Monday in Louisville.
The Cardinals have won five straight games since an 84-61 loss at Connecticut on February 9.
Before a crowd of 1,088 on Cincinnati's Senior Day, Bearcats' senior Jeanise Randolph had 22 points and 11 rebounds — her ninth double-double of the season and 14th of her career.
Alyesha Lovett added 15 points for Cincinnati (12-16, 5-12).