UConn All-American Kaleena Mosqueda-Lewis will miss three to six weeks with mononucleosis, the school announced on Friday.
Her absence leaves the No. 1 Huskies with just eight healthy players.
The junior forward was averaging 12 points and almost five rebounds for the Huskies. She already missed eight games earlier this season after suffering a nerve contusion on her right elbow.
The Huskies started the season with an 11-player roster. That has dwindled due to injury. Forward Morgan Tuck is out for the season after undergoing knee surgery last month.
Guard Brianna Banks has missed three of the past five games with an injured ankle. The Huskies visit South Florida on Sunday.
If Banks can't play, the Huskies would have just six scholarship players in uniform.