Top-ranked and unbeaten Syracuse travels to No. 25 Pittsburgh on Wednesday to begin the most difficult portion of its schedule.
Syracuse ran its record to 23-0 and remained one of two unbeaten teams in Division I with a 57-44 victory over Clemson at home on Sunday night.
But Orange coach Jim Boeheim had to make some adjustments after backup center Baye Moussa Keita suffered a right knee injury late in the first half and starting center Rakeem Christmas picked up his fourth foul early in the second.
The status of the 6-foot-10 Keita, one of the Orange's top defenders, for the Pitt game is unknown.
The Panthers are coming off a double-overtime victory over Virginia Tech at home, where they've suddenly become somewhat vulnerable.