Cassandra Brown scored 18 points and twice nailed back-to-back 3-pointers midway through the second half, each time pushing Portland into double-digit leads as the Pilots stunned 24th-ranked and unbeaten San Diego 72-51 Wednesday night.
Brown, first off the bench for Portland, hit 6 of 7 shots, including 4-for-4 from 3-point range.
The Toreros (15-1, 4-1 West Coast Conference), ranked for the first time in program history, shot 29 percent from the field, their worst shooting this season.
Portland (9-6, 2-2) was unawed by the undefeated and ranked Toreros, holding a 45-33 rebounding edge and leading by seven at halftime.
San Diego's Felicia Wijenberg (a career-high 28 points) scored seven in a 9-0 run to get to 50-42.
But Brown one again drilled a pair of 3s as the Pilots boomed back up by 14 and San Diego didn't challenge again.
San Diego visits nine-time defending WCC champion Gonzaga Saturday.