Kellen Dunham scored 15 points and Khyle Marshall added 14 Monday night, leading Butler to a record-setting 100-41 over Manchester.
The 59-point margin broke the school's modern-day mark for most lopsided victory. The previous record came in an 87-33 win over Indiana-South Bend on Nov. 2, 2008.
Butler (7-2) also reached the 100-point mark for the first time in more than 12 years, improving to 5-0 at home and 6-0 in games played in Indiana this season.
Manchester (1-8), an NCAA Division III school, just couldn't match up with bigger, stronger Butler as it lost for the fourth straight time.
Brady Dolezal scored 14 points to lead the Spartans but none of his teammates reached double figures.
Butler seized control over the final 12 minutes of the first half, outscoring Manchester 33-12 to take a 48-24 halftime lead.
It was a complete mismatch.
Butler, which shot 61.5 percent in the second half of Saturday's victory over North Dakota, took advantage of its size to make 62.5 percent of its shots in the first half and finished with a season-high shooting percentage of 63.3.
The Bulldogs made it look easy, too.
They scored the first six points and never trailed. They had four dunks in the first eight minutes and seven in the game, and they limited Manchester to 17 points and only four baskets in the second half of a game that was never close over the final 30 minutes.
Manchester hung around briefly early, trailing just 15-12 after 7 ½ minutes.
But Woods stole the ball and drove in for a breakaway dunk to start a 13-0 spurt that made it 28-12 with 9:16 left in the first half.
When the Spartans closed the gap to 37-24 with 4:21 left in the half, Butler again turned up the pressure. The defense held Manchester scoreless the rest of the half, and another dunk from Woods sent Butler on a half-closing 11-0 run to make it 48-24.
The Bulldogs weren't finished.
They opened the second half on a 12-0 run, pulling out to a 60-24 lead less than three minutes into the second half.
After Manchester finally ended a field goal drought of about nine minutes, Butler went on a 10-0 spurt to take a 73-29 lead leaving just one lingering question: Could the Bulldogs hit 100 points for the first time since beating Evansville 101-65 on Dec. 8, 2001? Little-used guard Michael Volovic made it a reality by making with two free throws with 1:19 to play.