Markel Starks scored 18 points and D'Vauntes Smith-Rivera added 17, and Georgetown pulled away early in the second half for an 80-45 win over High Point Thursday night.
Joshua Smith contributed 11 points for the Hoyas (5-2), who won their fourth straight.
Georgetown led by 12 at halftime and pulled away by scoring the first 10 points of the second half in the first-ever meeting between the schools. The Hoyas led by as many as 40 points.
The Big South Conference Panthers (3-4) were led by Jorge Perez-Laham's 10 points.
Starks scored five quick points on a layup and 3-pointer to open the second half. Smith added a three-point play and Nate Lubick's hook shot made it 38-16 two minutes in.
The Panthers turned the ball over on three of their first four second-half possessions.
High Point was without starter Allan Chaney, who missed his second game since collapsing on the court during the team's Nov. 24 game against Wofford.
Perez-Laham's 3-pointer cut the High Point deficit to 40-23, but Georgetown went on a 15-2 run keyed by 10 points from Smith-Rivera.
The Hoyas scored 42 points in the paint and tied a season-high with 10 three pointers, shooting 55.2 percent (32 of 58) from the field, including 41.7 percent from 3-point range.
The Panthers hit just 16 of 57 shots (28.1 percent), including 3 of 21 from beyond the arc.
John Brown, who came in averaging 21.7 points for High Point and shooting 64 percent from the field, was held to eight points on 4-of-11 shooting.
Georgetown was content to shoot over High Point's zone defense and it paid off early on. The Hoyas made their first five shots, including three 3-pointers, and Smith's dunk made it 13-4 four minutes in.
Georgetown cooled off, but the Panthers didn't take advantage. High Point began play shooting 51 percent from the field, but made just 5 of 27 shots in the first half.
Starks' runner gave Georgetown its biggest lead of the half, 26-11.
The Panthers got to within 26-16 on Adam Weary's two free throws with 2:13 left, and the Hoyas led by 12 at intermission.
Georgetown improved to 13-0 against schools from the Big South.