Tricia Liston scored 20 points and Richa Jackson added 15 to help No. 2 Duke beat Alabama 92-57 on Sunday.
The Blue Devils (3-0) posted the 400th win at Cameron Indoor Stadium in program history.
Elizabeth Williams scored 13 points and Alexis Jones had 12 points to help Duke extend its home winning streak against unranked opponents to 124 games.
Haley Peters added 12 points and 12 rebounds for the Blue Devils.
Khadijah Carter and Shafontaye Myers scored 13 points each to lead Alabama (0-3). Karyla Middlebrook added 11 points and Daisha Simmons had 10 points for the Crimson Tide.
Duke opened the game with a 19-4 spurt and led 31-8 midway through the first half. The Blue Devils made 12 of their first 16 shots from the floor and shot 52 percent for the game.