Emani White hit a 3-pointer for Nicholls State on the game's first shot at No. 9 Baylor.
After White made another long-range shot 2½ minutes later, the Colonels never led again.
Freshman forward Nina Davis had 28 points and 11 rebounds in her first career start, preseason All-America point guard Odyssey Sims had 23 points and the Lady Bears won 111-58 on Thursday night. They extended the nation's longest active home winning streak to 59 games.
"You just have to give Baylor the credit in terms of their personnel, the depth they have and the ability they can, in a good way, just wear you down," Nicholls State coach DoBee Plaisance said. "They're outstanding. ... Odyssey did an outstanding job, especially in the first half, just nailing those 3s, which is expected. That's why she is who she is."
Mariana Lilly had 14 points on 7-of-9 shooting for the Colonels (1-1). White, who fouled out with 7 minutes to play, had 12.
Coming off a 33-point performance in the season opener, White scored eight points in the quick opening spurt. Her 3-pointer at the 17:17 mark made it 8-6.
Sune Agbuke hit a tying jumper before Baylor (2-0) went ahead to stay on a jumper by Makenzie Robertson with 16:40 left. That was part of 11 consecutive points to start a 30-8 run.
"I'm OK. And we'll be fine," Plaisance said. "This was an outstanding opportunity for us. I appreciate (Baylor coach Kim Mulkey) and her team and her hospitality. Everybody around here has been so gracious to us. I'm just excited about the opportunity for us to come up here. I think for about 75 percent of the game, relatively speaking, we were doing OK."
Senior point guard Sims, Baylor's only returning starter, had four 3-pointers. Freshman Khadijiah Cave had 17 points and 11 rebounds while Imani Wright, yet another first-year Lady Bears player, scored 15 points.
Sims, who got to sit back and watch while not playing the last 10 minutes, was hoping that Davis would reach 30 points.
"I wanted her to score as many points as she could. It's always fun to watch another teammate get a double-double," Sims said before looking at her coach. "And not to mention, she was player of the game, so I think she should start all the time."
Baylor has scored at least 110 points in both games in its first season after the departure of 6-foot-8 Brittney Griner, the two-time AP Player of the Year, and three other senior starters. The Lady Bears last had consecutive 100-point games in December 2006.
The Lady Bears broke 100 points once in each of the last two seasons, including during the 2011-12 national championship run when they finished 40-0. The most points they scored in Griner's four seasons was 109.