No. 23 Texas has lost leading rusher Johnathan Gray for the season to a torn Achilles tendon.
He had rushed for 780 yards, the third-most in the Big 12, and four touchdowns this year. He was hurt Saturday in an overtime win at West Virginia.
Senior defensive tackle Chris Whaley also suffered a season-ending injury in the 47-40 win.
Junior Malcolm Brown is expected to take over as the featured running back.
Texas (7-2, 6-0 Big 12) hosts No. 12 Oklahoma State (8-1, 5-1) this Saturday.