Jody Wynn watched one of her best players go down late in the first half and limp off the court with help, grabbing her left knee.

"I was scared to death," the Long Beach State coach said.

The 49ers already had three women sidelined. So, when Anna Kim insisted on returning in the second half of a 70-51 loss to No. 9 California on Friday night, Wynn could breathe again.

Kim scored 11 points to lead Long Beach State despite the injury, but the 49ers lost their fifth straight to Cal in the season opener for both schools.

Kim went down 5:07 before halftime. An athletic trainer worked on her left knee on the bench and she rode a stationary bike behind the bench before returning in the second half with the knee wrapped.

Wynn said Kim will undergo an MRI exam once back home in Southern California, and initial evaluations by Cal doctors showed a possible hamstring injury.

"She was courageous to get back out there and compete," Wynn said. "She was on the one who said, 'Hey, I'm going to get back in the game.'"

Afure Jemerigbe scored 13 points, freshman Mercedes Jefflo made seven steals in an impressive collegiate debut, and Cal overcame a cold-shooting first half for its 16th straight regular-season win dating to last season.

Long Beach State junior guard and leading scorer Alex Sanchez, the only player back who averaged double digits last season, was held to nine points on 3-for-13 shooting. After Sanchez hit one free throw 10 seconds into the game, the 49ers were held scoreless over the next five minutes.

The teams played for the first time since Cal's 82-76 victory on Dec. 11, 2010.

Wynn has the core of her team back this year, with seven returners and four starters, after a 16-16 finish and berth in the Women's National Invitation Tournament. Yet junior likely starters Chantel Dooley and Devin Hudson didn't play in the opener as they are still recovering from offseason knee surgeries. Junior guard Bianka Balthazar also sat out while healing from concussions.

For Cal, senior Gennifer Brandon returned three months to the day after surgery to place a rod in her lower right leg to alleviate recurring stress fractures.

"I was a little apprehensive. Emotionally I felt wonderful, feeling the energy of my team," Brandon said. "There were some surprising moments just being out here today is a surprise to me still. I'm still trying to embrace it, it's beautiful."

Jefflo added nine points and three assists, scoring consecutive baskets early in the second half as the Golden Bears pulled away to run their regular-season winning streak to 16 games dating to last season.

Third-year coach Lindsay Gottlieb and her players hope to build off the program's first Final Four berth in school history last season, when Cal shared the Pac-12 title with Bay Area rival Stanford.

The big test comes Sunday afternoon on Cal's home court: A date with second-ranked Duke.

"A marquee game in November big-picture wise is something we're proud of," Gottlieb said. "We want to be in that kind of game to measure ourselves."

Gottlieb got word Wednesday that Brandon would be able to play limited minutes. She checked in at the 13:56 mark of the first half.

"She's my superhuman bionic child," Gottlieb said.

Brandon, an all-Pac-12 player who averaged 12.3 points last season, had six points and that leaping blocked shot in 13 minutes of action.

"I've always referred to Genn Brandon as a pogo stick," Wynn said. "Not too many kids in the country have that kind of athleticism."

Reshanda Gray had 10 points and 11 rebounds for Cal, and 6-3 freshman Courtney Range 14 boards.

Jemerigbe scored five straight points late in the first half as Cal took a 27-18 lead at the break despite shooting 28.6 percent.

The Bears, with seven players returning from last season's history-making NCAA tournament run, are picked to finish second in the conference behind the Cardinal.

Junior guard and top returning scorer Brittany Boyd sat all but eight minutes of the first half in foul trouble, then scored all six of her points after intermission to go with seven rebounds, four assists and four steals. She will be looked upon to carry a bigger load after Cal lost leading scorer Layshia Clarendon.

Boyd fouled Kim on a made 3-pointer for her second personal and Kim converted the four-point play to tie the game at 12 with 10:12 left in the opening half, sending Boyd to the bench.