Corey Perry scored with 2:25 remaining in the third period on Sunday night and the Anaheim Ducks edged Columbus 4-3, ending Blue Jackets' three-game winning streak.
Perry wristed a shot over a sprawled Sergei Bobrovsky for his sixth of the season. A pass by Columbus' Dalton Prout behind the net caromed hard off the back boards to Perry in the slot.
The Ducks lost Saku Koivu late in the second period on a hit that resulted in the ejection of Columbus' Brandon Dubinsky.
Artem Anisimov scored twice, rebounding from a first-period hit by Francois Beauchemin, and Blake Comeau scored his first of the season for Columbus, which finished a four-game homestand at 3-1.
Bobrovsky, last season's Vezina Trophy winner, stopped 28 of 32 shots.
Ryan Getzlaf, Peter Holland and Emerson Etem scored for Anaheim.