Right guard Louis Vasquez will move to right tackles and Denver will start backup left guard Chris Kuper in Vasquez's normal spot Sunday night at Indianapolis.
The Broncos made the changes because starting right tackle Orlando Franklin is inactive with a sprained left knee.
Middle linebacker Wesley Woodyard also is inactive with a shoulder stinger and will be replaced in the starting lineup by Paris Lennon.
Denver's other inactives are running back C.J. Anderson, cornerbacks Tony Carter and Quentin Jammer, quarterback Zac Dysert and guard John Moffitt.
Indy does not have any lineup changes. Defensive linemen Josh Chapman and Montori Hughes, offensive linemen Khaled Holmes and Xavier Nixon, tight end Dominique Jones, receiver David Reed and linebacker Bjoern Werner are all inactive for Indy.
AP NFL website: www.pro32.ap.org