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Colin Kaepernick combines for 267 yards as 49ers rout Titans 31-17 for 4th straight win

  • 743f55f46203c523400f6a706700510a.jpg

    San Francisco 49ers quarterback Colin Kaepernick (7) celebrates after scoring a touchdown against the Tennessee Titans on a 20-yard run in the second quarter of an NFL football game on Sunday, Oct. 20, 2013, in Nashville, Tenn. (AP Photo/Mark Zaleski) (The Associated Press)

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    San Francisco 49ers quarterback Colin Kaepernick (7) gets past Tennessee Titans linebacker Akeem Ayers (56) during the second half of an NFL football game on Sunday, Oct. 20, 2013, in Nashville, Tenn. (AP Photo/Wade Payne) (The Associated Press)

  • fc911685622dc623400f6a706700e9fb.jpg

    San Francisco 49ers running back Frank Gore (21) heads to the sideline with Bruce Miller (49) and Anthony Davis (76) after Gore scored a touchdown on a 1-yard run against the Tennessee Titans in the third quarter of an NFL football game on Sunday, Oct. 20, 2013, in Nashville, Tenn. (AP Photo/Mark Zaleski) (The Associated Press)

  • b1fef6f76239c623400f6a7067005853.jpg

    San Francisco 49ers tight end Vernon Davis (85) is knocked out of bounds by Tennessee Titans defenders Bernard Pollard (31) and Zach Brown, left, in the second half an NFL football game on Sunday, Oct. 20, 2013, in Nashville, Tenn. (AP Photo/Mark Zaleski) (The Associated Press)

  • e87b240c61c9c423400f6a706700cb15.jpg

    Tennessee Titans quarterback Jake Locker (10) passes as San Francisco 49ers linebacker Ahmad Brooks (55) rushes in the first quarter of an NFL football game on Sunday, Oct. 20, 2013, in Nashville, Tenn. It is the first start for Locker since returning from a hip injury. (AP Photo/Mark Humphrey) (The Associated Press)

Colin Kaepernick threw for 199 yards and ran for 68 and a touchdown, helping the San Francisco 49ers start their longest road trip this season by beating the Tennessee Titans 31-17 Sunday.

The 49ers (5-2) won their fourth straight before heading to London for a game with winless Jacksonville by jumping out to a 17-0 halftime lead. Frank Gore also ran for a pair of 1-yard TDs as San Francisco cruised.

Tramaine Brock also intercepted a pass, Justin Smith had two of the 49ers' three sacks and Kassim Osgood recovered a muffed punt for a TD.

The Titans (3-4) lost their third straight even with Jake Locker starting after missing two games with a sprained right hip and knee. Locker threw for 326 yards with two TD passes in a fourth-quarter spurt that came up short.

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AP NFL website: www.pro32.ap.org