Arizona sacked Cam Newton seven times, once for a safety, and intercepted him on three occasions to overcome a sluggish offensive performance, and the Cardinals beat the Carolina Panthers 22-6 on Sunday.
Daryl Washington, back after serving a four-game suspension for violating the NFL's substance abuse policy, had two sacks and an interception for Arizona (3-2).
Calais Campbell had two sacks, one for Arizona's first regular-season safety in nine years, the other forcing a game-clinching fumble. Karlos Dansby also had two sacks and an interception.
Carolina (1-3), playing for the first time since a 38-0 victory over the New York Giants two weeks ago, managed only Graham Gano's field goals of 22 and 51 yards.
Arizona's Carson Palmer threw for a touchdown but was intercepted three times.