Busch Stadium will be the site of its second international soccer game this year when the Argentine national team faces Bosnia-Herzogovina on Nov. 18.
An overflow crowd of 48,263 attended Manchester City's 4-3 exhibition win over rival Chelsea in May.
If Bosnia-Herzogovina fails to qualify for the 2014 World Cup, it will be replaced by a team to be determined. The country currently leads Greece in Group G qualifying. The Bosnians host Lichtenstein on Oct. 11 and play at Lithuania on Oct. 15 to close out the final round of qualifying.
Argentina is led by FC Barcelona star Lionel Messi and has already qualified for the World Cup in Brazil next year.