Sean Mannion passed for 414 yards and a school-record six touchdowns and Oregon State won its fourth consecutive game Saturday with a 44-17 victory over Colorado.
Brandin Cooks caught nine passes for 168 yards and two touchdowns for the Beavers (4-1, 2-0 Pac-12), and had five carries for 47 yards.
Mannion battled gusty wind conditions to complete 27 of 52 passes.
Caleb Smith also caught two touchdowns passes for the Beavers, who never trailed.
Colorado (2-1, 0-1) played its first game in three weeks. Flooding postponed the Buffaloes' Sept. 14 game against Fresno State, in addition to a bye week.
The Buffaloes' offense was out of sync for most of the game. Quarterback Connor Wood connected on just 14 of 34 passes for 146 yards. Paul Richardson, who came into game as the country's leading receiver averaging 208.5 yards per game, was held to five receptions for 70 yards.