Second-half goals from Mehdi Benatia and Gervinho helped Roma to a 2-0 win at Sampdoria on Wednesday that continues Roma's perfect start to the season.
With five wins from five games Roma is off to its best start ever in Serie A, while the club sits alone atop the league with Napoli being held to a 1-1 draw by last-place Sassuolo on Wednesday.
The visitors created the best openings in the match, but they didn't open the scoring until after manager Rudi Garcia was sent off early in the second half.
Benatia broke the deadlock in the 65th minute when he dribbled his way through the Sampdoria defense, and despite being fouled, he was still able to tuck the ball inside the far post.
Francesco Totti was left on the Roma bench to start the match, but he came into the game and set up the second goal on the break, sliding the ball to Gervinho to allow the former Arsenal man to tally his first goal for the club.
A frustrating night for the home side was capped off with Antonino Barilla receiving two yellow cards in quick succession as the match entered stoppage time.
Napoli will be disappointed to have dropped points at home against Sassuolo, which entered the match having lost its first four games.
Blerim Dzemaili put Napoli in front after 14 minutes, but Simone Zaza answered six minutes later for Sassuolo to give the visitors an unlikely point.
Juventus collected a 2-1 win at Chievo but needed two goals in the second half to overcome a halftime deficit.
Fabio Quagliarella scored shortly after the break for Juve to cancel out Cyril Thereau's first-half opener, while the difference came in the 65th when Chievo's Alessandro Bernardini scored an own goal.
AC Milan's struggles continued on Wednesday as the club needed to come from two goals down against Bologna just to slip away with a 3-3 draw.
Goals from Robinho and Ignazio Abate in the last few minutes saved the Rossoneri, but the club is now 10 points adrift of the top spot.
Lazio won for the third time in five games by topping Catania, 3-1, Livorno and Cagliari played out a 1-1 draw, Marco Parolo scored twice as Parma held off Atalanta, 4-3, and Jorginho converted a second-half penalty kick to help Hellas Verona to a 2-2 draw at Torino, which got both of its goals from Alessio Cerci.