Colts safety LaRon Landry is listed as out for Sunday's game at San Francisco.
The Pro Bowler has not practiced this week because of an ankle injury. Indy (1-1) also could be without linebacker Pat Angerer, who has a knee injury. He is listed as doubtful.
It could be even worse for the already short-handed Colts. Defensive end Cory Redding (back) and center Samson Satele (elbow) did not practice Friday and are questionable, along with safety Antoine Bethea (toe).
Receivers Darrius Hewyard-Bey (ribs), T.Y. Hilton (groin), David Reed (quad) and Reggie Wayne (shoulder) and linebacker Kavell Conner (ankle) are all probable. Tight end Dwayne Allen, running back Vick Ballard and left guard Donald Thomas are already on Indy's injured reserve list.