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Colts-49ers Capsule

INDIANAPOLIS (1-1) at SAN FRANCISCO (1-1)

4:25 p.m. ET, CBS

OPENING LINE — 49ers by 10 1/2

RECORD VS. SPREAD — Indianapolis 0-2, San Francisco 1-1

SERIES RECORD — Colts lead 24-18

LAST MEETING — Colts beat 49ers 18-14, Nov. 1, 2009

LAST WEEK — Colts lost to Dolphins 24-20; 49ers lost to Seahawks 29-3

AP PRO32 RANKING — Colts No. 15; 49ers No. 3

COLTS OFFENSE — OVERALL (14T), RUSH (5), PASS (19)

COLTS DEFENSE — OVERALL (23), RUSH (29), PASS (16)

49ERS OFFENSE — OVERALL (17), RUSH (17), PASS (18)

49ERS DEFENSE — OVERALL (13T), RUSH (25), PASS (10)

STREAKS, STATS AND NOTES — Indianapolis won last two meetings. ... Colts make first visit to Candlestick Park since 28-3 win Oct. 9, 2005, in first start by '05 No. 1 overall draft pick Alex Smith for San Francisco vs. Peyton Manning. ... That marked last time before Sunday's five-turnover loss at Seahawks that 49ers had more turnovers than points. San Francisco had five turnovers and no TDs for just third time since 1979. ... Colts' 2009 win vs. 49ers was team's 16th straight regular-season victory at time. ... First matchup between 49ers TE Vernon Davis and cornerback brother Vontae of Colts. Big brother Vernon nursing hamstring injury, however. ... Colts QB Andrew Luck coached by Jim Harbaugh at Stanford. ... Luck has thrown for 499 yards this season to 539 by 49ers' Colin Kaepernick. Each has three TD passes, Kaepernick three INTs, Luck one. ... Luck has been sacked seven times in first two games for 37 yards; Kaepernick five times for 28 yards. ... Indy added RB Trent Richardson in trade with Cleveland days after starter Vick Ballard tore up knee. ... Harbaugh played four seasons for Colts from 1994-97 and earned "Captain Comeback" nickname. Inducted into team's Ring of Honor in 2005. ... 49ers WR Anquan Boldin set Baltimore franchise record with 145 yards receiving and caught clinching touchdown in Ravens' 24-9 victory vs. Colts in January's AFC wild-card game before being traded to San Francisco in offseason. ... Boldin has 14 catches for 366 yards and two TDs in four career games against Colts. ... 49ers have won last five games vs. AFC opponents and Harbaugh's teams are 7-1 overall in regular season against AFC. ... ... 49ers will start Glenn Dorsey at NT after losing Ian Williams to season-ending broken left ankle in loss to Seahawks.

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AP NFL website: www.pro32.ap.org