Andrew Luck ran 19 yards for the winning touchdown Sunday, giving Indianapolis a 21-17 season-opening victory over Oakland.
Luck was 18 of 23 for 178 yards with two touchdown passes, but earned his eighth career fourth-quarter comeback by scrambling for a score with 5:20 to go in the game.
It was Indianapolis' first opening-day win since 2009.
Oakland started Terrelle Pryor at quarterback. He was 19 of 29 for 217 yards and one TD, and he broke the Raiders rushing record for a quarterback with 13 carries for 112 yards.
But he also threw two interceptions in the red zone, the second coming with 25 seconds left in the game to seal Indy's victory.
Luck led the Colts to TD drives on their first two possessions, but didn't score again until Luck's go-ahead score.
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