Jesus Guzman singled home Kyle Blanks in the ninth inning as the San Diego Padres edged the Colorado Rockies, 4-3, on Friday.
Todd Helton's leadoff homer in the top of the ninth gave Colorado a 3-2 lead, but Chase Headley led off with a homer of his own in the home half, a towering shot to left field off Rex Brothers, to tie the game.
Blanks followed with a walk and Alexi Amarista reached on a bunt single. Ronny Cedeno moved the runners into scoring position and Brothers walked Nick Hundley to load the bases.
Guzman followed with a line drive single just inside the third base line that scored Blanks for the game-winning run.
"I think that game was Chase Headley," Guzman said. "He won the game because he changed the game. If he didn't change the game, I don't get that hit."
Will Venable also hit a solo homer for the Padres, winners in three of their last four games.
Huston Street (2-4) earned the win despite giving up Helton's homer in the ninth inning. Starter Burch Smith allowed two runs on four hits and four walks while striking out a career-high seven over five innings.
Troy Tulowitzki and Michael Cuddyer drove in one run apiece for the Rockies, who saw starter Juan Nicasio give up two runs -- one earned -- on four hits while fanning seven over six innings.
Brothers (2-1) was pegged with the loss.
"If you make bad pitches, you get beat in this league," Brothers said.
The Rockies scored a pair of runs in the first inning. Dexter Fowler led off with a double and DJ LeMahieu followed with a single to put runners on the corners. Tulowitzki followed with a double to center to score Fowler. LeMahieu scored on Cuddyer's fielder choice.
Venable's leadoff homer in the home half made it 2-1.
The Padres tied the game in the sixth. Chris Denorfia walked then scored on Jedd Gyorko's ground out to third. Gyorko tapped a chopper to the left side and was thrown out at first by LeMahieu. Helton then fired it back across the diamond to get Denorfia, who was going from first to third on the play.
No one covered third on the play, however, and Helton's throw bounced off the wall in shallow left field. Wilin Rosario, who was racing down the line to cover third, recovered the ball off the carom and fired home, but Denorfia made an incredible slide to avoid the tag at the plate and tie the game.
The Padres were 1-for-7 with runners in scoring position ... Headley, who entered Thursday with a 99-game homerless streak, has homered in back-to-back games ... The Rockies were 2-for-9 with RISP ... Helton hit his 367th career homer, putting him in sole possession of 75th place all-time.