Andrew Luck went 16-for-25 for 164 yards, two touchdowns and an interception, as the Indianapolis Colts defeated the Cleveland Browns, 27-6, on Saturday.
Luck also ran four times for 20 yards for the Colts. Seven of his completions went to Reggie Wayne, who finished with 79 yards. Kerwynn Williams led the game in rushing with nine carries for 37 yards.
Brandon Weeden completed just 12-of-25 passes for 105 yards while Jason Campbell went 8-for-14 for 112 yards for the Browns, who were penalized nine times in the contest. Trent Richardson rushed seven times for 31 yards.
The Browns were held scoreless and limited to just 104 total yards in the first half.
Adam Vinatieri drilled a 32-yard field goal midway through the first quarter to put Indianapolis on the board.
In the second, Luck found Stanley Havili for a 3-yard touchdown. He extended the Colts' lead even further on their opening drive of the third quarter, throwing an 8-yard touchdown strike to T.Y. Hilton for a 17-0 advantage.
Shayne Graham got the Browns on the board with 7:16 left in the period after booting a 50-yard field goal. However, Vinatieri responded late in the quarter, nailing a 25-yard field goal to give the Colts a 20-3 lead.
In the fourth, Graham split the uprights from 44 yards out with 4:33 remaining and the Browns followed by recovering an onside kick. However, on the first play, Brian Hoyer threw a short pass intended for Cordell Roberson and was intercepted by Larry Asante, who returned it 48 yards for the score.