Jeff Tuel tossed a pair of touchdown passes, part of a 19-of-23, 212-yard performance in Buffalo's 44-20 demolition of Indianapolis in the exhibition opener for both clubs on Sunday.
E.J. Manuel added 107 yards and a score through the air on 16-of-21 efficiency for Buffalo, while Marcus Easley led all receivers with 94 yards on seven receptions.
Brandon Kaufman and Dorin Dickerson posted a receiving TD each, to offset C.J. Spiller's 36-yard day in limited action. Marquise Goodwin made his presence known with a 107-yard kickoff scamper to paydirt.
Andrew Luck finished 4-of-6 for 51 yards, while Chandler Harnish completed 14- of-33 passes for 109 yards and an interception for the Colts.
T.Y. Hilton snagged three balls for 61 yards, including a 45-yard score from Matt Hasselbeck, and Dax Swanson returned a fumble 72 yards for a touchdown.