Top seed Milos Raonic suffered a second-round upset Wednesday at the $625,000 Aegon International, a final grass-court Wimbledon tune-up.
Capable Croat Ivan Dodig sent the Canadian world No. 15 Raonic packing in 6-2, 7-6 (9-7) fashion on Day 3 at Devonshire Park. The big-serving Raonic popped nine aces in an 83-minute losing effort.
"I couldn't have started in a worse way," Raonic said. "I think I missed four backhands to start off the match. I had my chance in the tiebreak. But I don't think I should let situations where I get two double faults from my opponent pass by and not win a tiebreak. I can't play much worse, so it's only going to get better."
Second-seeded Frenchman Gilles Simon stayed alive by besting British wild card Kyle Edmund in a pair of tiebreaks, 7-6 (7-5), 7-6 (7-3), while more upsets came when Czech veteran Radek Stepanek doused third-seeded German Philipp Kohlschreiber 7-5, 6-3 and Spanish left-hander Feliciano Lopez dismissed fourth-seeded Argentine Juan Monaco 6-4, 6-4.
A pair Italian seeds avoided the upset bug, as No. 7 Andreas Seppi overcame American qualifier Ryan Harrison 3-6, 7-5, 6-3 and No. 8 Fabio Fognini came back to beat Slovak Martin Klizan 6-7 (6-8), 6-2, 6-2. The 2011 Eastbourne champion Seppi was last year's runner-up here to since-retired American Andy Roddick.
In other second-round play, Spanish southpaw Fernando Verdasco drubbed compatriot Albert Ramos 6-4, 6-0 and Aussie Bernard Tomic held off quality Frenchman Julien Benneteau 6-2, 5-7, 7-6 (7-4).
The quarterfinals will pit Simon against Tomic, Seppi versus Stepanek, Fognini against Dodig, and Lopez versus his fellow left-handed countryman Verdasco.
The 2013 Eastbourne champion will collect $113,000.