Joey DeNato threw a four-hitter and Indiana looked right at home in beating Louisville 2-0 on Saturday night in the Hoosiers' first appearance in the College World Series.
The Hoosiers manufactured their runs early, and DeNato (10-2) made them stand up in a masterful performance in front of a TD Ameritrade Park-record crowd of 27,122.
Indiana (49-18) has beaten the Cardinals (51-13) in three of four meetings, shutting them out twice. The Hoosiers will play Monday against Mississippi State, and the Cardinals will face Oregon State in an elimination game.
DeNato allowed three singles and a double in his second complete game. He struck out eight and walked three.
Cody Green (10-4) took the loss.
Indiana is the first Big Ten team in the CWS since Michigan in 1984 and gave the conference its first win in Omaha since the Wolverines beat Stanford in 1983.