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Andy Pettitte tries to get the New York Yankees back into the win column on Friday when they play the first of three games against the Los Angeles Angels of Anaheim at Angel Stadium.

New York started its 10-game road trip in successful fashion by taking three of four in Seattle. However, the Yanks stumbled after that, as they were swept in a three-game set by the Oakland Athletics and saw their offense disappear in Thursday's 3-2, 18-inning loss.

"We had two runs in the first, and that was it," Yankees manager Joe Girardi said. "We had a ton of opportunities and weren't able to cash in. It's frustrating, but you've got to turn the page."

Robinson Cano went 3-for-6 with a two-run homer for the Yankees, who went 1- for-13 with runners in scoring position and left 14 men on base. Mark Teixeira, Travis Hafner, Kevin Youkilis and Vernon Wells were a combined 0- for-28 with three walks and 12 strikeouts in the game.

Hoping for a little more support on Friday will be Pettitte, who picked up career win No. 250 on Saturday against the Mariners. Pettitte allowed a run and three hits over 7 1/3 innings of that one to run his record to 5-3 this season, while lowering his ERA to 3.82.

Pettitte, though, has struggled against the Angels of late, posting a mere 2-5 mark with a 5.83 ERA in nine regular-season starts since 2008. For his career, he is 14-11 with a 4.49 ERA in 31 career starts against them.

Los Angeles, meanwhile, will counter with a left-hander of its own in C.J. Wilson, who is 4-5 with a 4.02 ERA. Wilson lost his second straight start on Saturday in Boston, as the Red Sox reached him for four runs (3 earned) and eight hits in just five innings.

"That's pretty garbage," Wilson said. "It's disappointing."

Wilson is 1-3 lifetime versus the Yankees with a 3.43 ERA in 23 games (6 starts).

Los Angeles salvaged the finale of its set with Baltimore on Wednesday, as Erick Aybar hit a three-run triple and Albert Pujols smacked a two-run homer as part of a six-run seventh inning to power the Angels to 9-5 victory at Camden Yards.

Hank Conger hit a solo homer, while Josh Hamilton and Howie Kendrick each drove in one run for the Angels, who put an end to a four-game skid.

"Definitely makes the road trip a lot better," Conger said. "We had a rough series and for us to try to end on a win right there, go back home and face the Yankees, that's going to be big for us."

Jerome Williams (5-2) allowed four runs on nine hits over six frames and struck out four in the victory.

New York won five of its nine meetings with the Angels last season.