Updated

Jim Harbaugh has used the recent run of suspensions on the division rival Seattle Seahawks for performance-enhancing drug infractions as a reminder for his own San Francisco team: Cheating won't be tolerated.

Harbaugh's reigning NFC champion 49ers had begun their three-day minicamp Tuesday when the coach was asked about the issue surrounding the Seahawks.

Harbaugh says: "It has no place in an athlete's body. Play by the rules."

Seattle defensive end Bruce Irvin was suspended last month for using a banned substance. A first-round draft pick last year, he will miss the first four games of the regular season.

Irvin became the fifth Seahawks player since 2011 to be suspended for using a performance-enhancing substance. The others were John Moffitt, Allen Barbre, Winston Guy and Brandon Browner.