Jessica Korda carded a 7-under 65 on Friday and moved one stroke clear of the field after two rounds of the Mobile Bay LPGA Classic.
Korda, last year's Women's Australian Open champ, completed 36 holes at 13- under-par 131. Her total of 131 smashed the tournament's 36-hole scoring record.
Cristie Kerr set the old mark of 135 in 2008 and that was later matched by Se Ri Pak and Stacy Lewis.
World Golf Hall of Famer Karrie Webb fired a 9-under 63 to move into second place at minus-12. Chella Choi is one shot behind Webb at 11-under 133 after a second-round 66.
Sydnee Michaels fired a course-record, 10-under 62 to soar into a share of fourth place at minus-10. She stands alongside Pornanong Phatlum (65) and Thidapa Suwannapura (67) on the Crossings Course, which is part of the Robert Trent Jones Golf Trail at Magnolia Grove.
Korda got off to a quick start with a birdie on the first. She birdied the fourth and sixth, both par-5s. Korda birdied the ninth to climb to 10-under.
The 20-year-old continued her strong play with a birdie at the par-4 11th. After three pars in a row, Korda converted back-to-back birdie tries at 15 and 16. She parred the last two to hang on to the lead.
"Yeah, definitely, it's been a long time. It feels good, though. I'm hitting the ball good and I'm having a lot of fun out there," said Korda, who took the last two weeks off to rest a wrist injury.
"I reached every single (par-5) today, so that's been really nice. This is definitely one of the stops I wanted to come back to and I hope we can keep this event as long as possible out here because I really like it."
Webb, who was inducted into the World Golf Hall of Fame in 2005, had one birdie and four pars through five holes. She dropped in back-to-back birdie chances from the sixth and again from the 10th to jump to minus-8.
The Australian birdied the 14th, then closed with three consecutive birdies from the 16th to get within one of the lead.
"I'm not sure the last time I had a bogey-free round, so I'm really happy about that. That's sort of been my problem is I have bogeys at the wrong time and it really kills momentum," Webb stated. "That's what happened yesterday, I turned at 2-under and then doubled one and bogeyed two and all of a sudden I'm at 1-over.
"I just was really happy with that fight back yesterday to finish at 3-under and I think that really carried over into today, and it was nice to play today without any bogeys."
Perhaps the round of the day belonged to tour rookie Lisa McCloskey. She poured in four birdies in a 5-hole span from the 11th, her second, to jump to 7-under. She closed with 12 consecutive pars to end six back, but that was just part of the story.
McCloskey and her mom were involved in a serious car accident on their way home from the course on Thursday. Other than a sore thumb and some scrapes from the air bags, McCloskey was fine physically.
"You know, I think I came out here with no expectations, just make-the-cut kind of thing. I probably would have been happy with even-par or a couple over," McCloskey admitted. "But I don't know, the putter was really working for me on the first nine, and then second back nine things kind of slowed down, I think I kind of got a little bit tired. But I finished with two really good pars, so I'm happy."
NOTES: First-round co-leader Lexi Thompson managed a 2-under 70 and fell into a share of seventh at minus-9, while her fellow first-round leader Eun-Hee Ji carded an even-par 72 and dipped into a tie for 15th at 7-under 137 ... The cut line fell at even-par 144 with 80 players advancing to the weekend ... Among those that missed the cut were Sophie Gustafson. Brittany Lincicome, Karen Stupples and Michelle Wie.