Fifth seed Jurgen Melzer and two- time defending champion Pablo Andujar were sent packing Tuesday at the Moroccan Grand Prix tennis event.
German Tobias Kamke upset the Austrian left-hander Melzer 6-3, 6-3, while qualifier Pablo Carreno-Busta knocked out his fellow Spaniard Andujar 6-4, 2-6, 6-3 on the red clay at Complexe Al Amal.
Andujar beat Albert Ramos in last year's all-Spanish finale here.
Another opening-round upset came when Spaniard Guillermo Garcia-Lopez took out sixth-seeded compatriot Daniel Gimeno-Traver 7-6 (7-5), 3-6, 6-3.
Eighth seed Grega Zemlja of Slovenia avoided an upset by overcoming German Matthias Bachinger 6-7 (3-7), 7-5, 7-6 (7-2) on Day 2.
Also on Tuesday, Swiss qualifier Henri Laaksonen beat Moroccan wild card Younes Rachidi, 6-3, 6-7 (8-10), 6-1; Slovenian Aljaz Bedene dropped Frenchman Marc Gicquel 6-1, 6-4; Italian qualifier Filippo Volandri foiled Frenchman Paul-Henri Mathieu 6-3, 7-5; and France's Edouard Roger-Vasselin came back to best Spaniard Albert Montanes 3-6, 6-4, 6-4. Mathieu beat Montanes in the 2007 Casablanca final.
The top seed this week is Swiss slugger Stan Wawrinka, who titled here in 2010 and will face Slovenian Blaz Kavcic in the second round on Wednesday.
The winner of this $525,000 tournament will earn $96,000.