Mike Conley and Zach Randolph paced Memphis with 20 and 17 points, respectively, and the Grizzlies easily handled the Portland Trail Blazers, 94-76, on Wednesday at Rose Garden.
Conley was 7-for-11 from the field and Randolph added eight rebounds as Memphis set a new franchise record for wins with its 51st victory of the season.
Ed Davis chipped in with a 12-point, 10-rebound performance and Tony Allen donated 14 points in the Grizzlies' fourth straight victory.
Damian Lillard and J.J. Hickson each scored 17 in Portland's sixth straight defeat. Wesley Matthews added 12 points and Meyers Leonard finished with 10 in the setback.
A strong shooting first quarter helped the Grizzlies jump out to 32-21 lead, which expanded to 18 points by the middle stages of the second on back-to-back scores from Randolph.
A reverse layup from Lillard briefly got Portland's deficit down to single- digits, but the Grizzlies answered with six straight points and took a 57-46 edge into the break.
Memphis shot 61.1 percent from the field in the first half and locked down defensively over the final two quarters to keep Portland from coming any closer than seven points. The Trail Blazers were just 14-for-41 from the field in the second half.
After two consecutive scores from Leonard had Portland within 63-56, Conley fired back with a triple to spark a 9-0 spurt, which created a 16-point edge for Memphis with three minutes left in the third.
Holding a 77-64 lead after three quarters, the Grizzlies pushed their advantage to 19 points before the final buzzer.
Memphis is 18-6 since the All-Star break ... The Grizzlies' previous franchise record for wins was set by the 2003-04 squad ... The Trail Blazers fell to 22-14 as host ... Portland's LaMarcus Aldridge sat for a fourth straight game with an ankle injury ... Memphis took the season series, 3-1.