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Choo hits first of Reds' 3 homers off Blanton, Reds beat Angels 5-4

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    Los Angeles Angels starting pitcher Joe Blanton stands by the mound after giving up a 2-run home run to Cincinnati Reds' Chris Heisey, rounding the bases at left, during the fifth inning of an interleague baseball game, Thursday, April 4, 2013, in Cincinnati. (AP Photo/Al Behrman) (The Associated Press)

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    Los Angeles Angels' Josh Hamilton flips his bat after striking out against the Cincinnati Reds in the first inning of an interleague baseball game, Thursday, April 4, 2013, in Cincinnati. (AP Photo/Al Behrman) (The Associated Press)

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    Los Angeles Angels left fielder Mark Trumbo can't reach a double hit off the top of the wall by Cincinnati Reds' Todd Frazier in the fourth inning of an interleague baseball game, Thursday, April 4, 2013, in Cincinnati. (AP Photo/Al Behrman) (The Associated Press)

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    Cincinnati Reds' Todd Frazier hits a double off Los Angeles Angels starting pitcher Joe Blanton during the fourth inning of an interleague baseball game, Thursday, April 4, 2013, in Cincinnati. (AP Photo/Al Behrman) (The Associated Press)

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    Cincinnati Reds' Shin-Soo Choo (17), of South Korea, rounds the bases past Los Angeles Angels third baseman Alberto Callaspo (6) after hitting a solo home run in the first inning of an interleague baseball game, Thursday, April 4, 2013, in Cincinnati. (AP Photo/Al Behrman) (The Associated Press)

Shin-Soo Choo homered on Joe Blanton's first pitch of the game Thursday, the first of Cincinnati's three homers off the right-hander, and the Reds pulled away to a 5-4 victory over the Los Angeles Angels.

The Reds took two of three during the first interleague series to open a season.

Todd Frazier had a solo homer off Blanton (0-1), and Chris Heisey's two-run shot put Cincinnati up 5-3 in the fifth. Blanton gave up five runs and seven hits in five innings.

Bronson Arroyo (1-0) gave up three runs in six innings, including Josh Hamilton's two-run single that was his first hit for the Angels. Albert Pujols drove in a pair of runs with a sacrifice fly and a groundout.

Aroldis Chapman pitched the ninth for his first save.