Dayan Viciedo hit a grand slam and a two-run double, Dewayne Wise and Jordan Danks also homered, and Gavin Floyd allowed one run over 5 1-3 innings in the Chicago White Sox's 15-3 victory over the Chicago Cubs on Friday.
The Sox beat their crosstown rival for the second time in two games this season.
Wise homered for the third time this spring, and Paul Konerko raised his average to .394 with a single and a double. Konerko also walked and scored two runs.
Floyd, an important piece in the middle of the White Sox's starting rotation, did not walk a batter and struck out five.
"Everything was working pretty good today," Floyd said. "I threw some changeups in there that were pretty good and I was using everything, so that's a good place to be. Working both sides of the plate. It was fun."
Viciedo's homer was a deep blast to right-center field.