Justin Harding of South Africa had an 8-under 64 on Wednesday to lead three players in a 36-hole qualifier who earned spots in the British Open for the first time.
Harding finished the International Final Qualifying in Africa at 14-under 130.
Eduardo De La Silva of Spain had a 66 and Darryn Lloyd of South Africa had a 69 on the East Course at Royal Johannesburg & Kensington to earn the other two spots.
Golf's oldest championship has 36-hole qualifying on five continents. The final two to be held will be later this year in Europe and the United States.
The British Open will be played July 18-21 at Muirfield.