Laura Sweeny scored a season-high 29 points and Rachel Roberts added 20 to help Villanova upset No. 22 Syracuse 77-75 in triple overtime Saturday.
Devon Kane, who hit a game-tying layup at the end of regulation, added 10 points for Villanova (19-6, 8-7), in just the second three-overtime game in Big East regular-season history.
Villanova jumped ahead 58-53 in the first overtime but went scoreless over the final 3 minutes as Syracuse (22-6, 10-5) rallied to force another extra frame.
Roberts' 3-pointer with 1:10 showing was the last basket of the second overtime, as the teams combined to miss four shots in the final minute.
The Wildcats snapped their cold streak in the final extra frame, opening with an 8-2 run to pull away for good.
Kayla Alexander and Carmen Tyson-Thomas each scored 22 points and grabbed 11 rebounds for Syracuse.