Justin Morneau homered in his final game with Minnesota before leaving for the World Baseball Classic, but the Twins lost to the Boston Red Sox 2-1 on Saturday.
Morneau, who will play for Canada in the WBC beginning Friday, led off the fourth inning with a drive that landed in a pond behind the right-field wall at Hammond Stadium.
Juan Carlos Linares went deep for Boston off starter Kyle Gibson, and the Red Sox took a 2-1 lead in the fifth when Jonathan Diaz scored on Ryan Sweeney's single.
Linares has yet to play in the major leagues.
The loss snapped a five-game winning streak for the Twins. Boston has won three consecutive games.
Attendance was 6,591 on a windy day.