Andrea Smith scored 18 points, Andrell Smith had 16 and Akila McDonald's only basket provided the winning margin as South Florida upset No. 21 Syracuse 68-66 Saturday.
It was the second consecutive win over a ranked team by the Bulls (19-7, 8-5 Big East), who beat No. 12 Louisville on Wednesday night and have won three straight.
The Orange (22-4, 10-3) had a six-game winning streak snapped.
Andrell Smith's 3-pointer just 3 seconds after a South Florida timeout with 5:57 remaining started a rally from a 59-52 deficit.
Another 3-pointer by Smith put the Bulls ahead 66-64 with 1:46 left, but Syracuse tied it on Carmen Tyson-Thomas' layup at the 41-second mark.
Following another South Florida timeout, McDonald scored the go-ahead layup with 24 seconds left on an assist by Andrea Smith.
Rachel Coffey missed twice for Syracuse in the closing seconds.
Tyson-Thomas led the Orange with 17 points.