Kelly Faris and Kaleena Mosqueda-Lewis each scored 18 points to help No. 3 Connecticut bounce back from its loss to top-ranked Baylor with a 90-30 rout of Seton Hall on Saturday.
The pair also both reached the 1,000-point plateau for their careers.
Breanna Stewart added 16 points for the Huskies (25-2, 12-1 Big East), who earned their 400th Big East win under head coach Geno Auriemma.
The win was the 29th straight for the Huskies over Seton Hall, and the 44th in 45 meetings.
Terry Green had 12 points for Seton Hall (9-18, 4-10), which lost for the 10th time in 12 games.
The Huskies led by 29 points at halftime and then held the Pirates without a basket for the first 6 1/2 minutes of the second half. The Huskies win assures them of a double-bye in the upcoming Big East tournament.
Faris, one of three seniors honored before the game, also had seven assists and seven steals.
Mosqueda-Lewis had 16 of her points in the first half as UConn built a 44-15 advantage. Stewart who hit her first five shots and Faris, who hit all four of her attempts in the first half, each had 10.
Stefanie Dolson, who finished with 12 points and nine rebounds, was the only other Husky to score before halftime.
Mosqueda-Lewis had three 3-pointers in UConn's game-opening 13-3 run. Her second made the sophomore the 37th player in UConn history to reach 1,000 points. Faris became the 38th with a second-half layup that made it 76-27.
A give-and-go assist from Mosqueda Lewis to Stewart highlighted a 14-0 run that put the Huskies up 30-8 and essentially put the game away.
The Huskies held Seton Hall to just 10 field goals and 20 percent shooting from the floor. Meanwhile UConn shot 52 percent, including 11-of-20 from 3-point range.
The Pirate came in averaging just 53.5 points per game, while the Huskies were leading the nation, averaging 82.5 points.
Mosqueda-Lewis hit her first four shots from behind the arc and finished 6-of-8 from long distance. She is the third fastest player in program history to reach 1,000 points, doing it in just 64 games. Only Maya Moore (55) and Svetlana Abrosimova (63) did it quicker.
UConn, which fell to Baylor 76-70 on Monday, hasn't lost back-to-back games in 20 years, a span of 720 games.
With the win, Geno Auriemma joins Stanford's Tara VanDerveer as the only women's basketball coaches to win 400 games in a single conference. VanDerveer won her 400th Pac-12 game when Stanford beat Oregon on Feb. 1.
Connecticut's seniors, Faris, Caroline Doty and Heather Buck, have won 132 games and lost just nine over the past four seasons. But Doty and Buck have been here five years because of illness and injury, and were part of teams that went 171-9 and won two national titles.
Faris, who made her 103rd consecutive start, had failed to score in double figures in three of her last four games.
Seton Hall was coming off a win over Providence, but had lost four in a row before that and has won just twice since January 9th.
The Pirates starters missed their first 15 shots, and Alexandra Maskeo fouled out with just under 10 minutes left in the game.
Seton Hall coach Anne Donovan will be spending a lot more time in Connecticut soon. The Pirates head coach is leaving the university at the end of the season to take over the WNBA's Connecticut Sun, which plays 30 miles away at the Mohegan Sun arena in Uncasville.