Bria Smith scored a career-high 21 points and Sara Hammond had 17 points and 13 rebounds to help No. 10 Louisville rout DePaul 81-55 on Sunday.
Smith, who scored 14 in the first half, was 13 of 15 from the free throw line and added seven rebounds. She scored 18 in Louisville's last outing, a 93-64 loss to No. 2 Notre Dame that snapped a six-game winning streak.
It was the fifth double-double for Hammond this season.
The Cardinals (21-5, 9-3 Big East) held DePaul to season-low 25 percent shooting (16 of 65) and dominated inside with a 50-10 advantage on points in the paint.
Chanise Jenkins led the Blue Demons (18-8, 7-5) with 16 points before fouling out with 5:11 remaining. Megan Podkowa had 14 points off the bench.
Louisville's win avenged an 86-80 Jan. 5 loss at DePaul earlier this season.