Russ Smith scored 18 points, Peyton Siva added 14 and No. 12 Louisville shot 52 percent to run away from No. 25 Marquette 70-51 on Sunday.
The lopsided outcome was somewhat surprising considering what was at stake for both teams in the Big East.
Marquette had an opportunity to take a one-game lead on Syracuse, but the Golden Eagles were left settling for a first-place tie with the Orange. The Cardinals (18-4, 6-3), meanwhile, moved a half-game closer to both schools with their second straight win, remaining in a four-way tie for third.
The Cardinals finished 27 of 52 from the field after an 0-for-8 start while holding the Golden Eagles (15-5, 6-2) to 36 percent shooting (19 of 53). They also outrebounded Marquette 38-26.
Gorgui Dieng added eight points and eight rebounds for Louisville.
Vander Blue had 17 points and Trent Lockett 16 for the Golden Eagles, who have dropped two of their last four games.