Cal head coach Lindsay Gottlieb earned her 100th career win in the Golden Bears' 72-45 rout of Oregon.
Talia Caldwell had 14 points and 14 rebounds for Cal (19-2, 9-1 Pac-12), which has won seven straight games.
Layshia Clarendon added 15 points and six boards in the triumph.
Devyn Galland netted 11 points for the Ducks (3-19, 1-9), which shot just 26.7 percent from the floor.
The Golden Bears jumped out to a 30-6 advantage before taking a 38-19 edge into the break. Cal went on a 17-0 run midway through the second half to put the contest out of reach.