Granada fired manager Juan Antonio Anquela on Wednesday with the club hovering just above the relegation zone.
Anquela's last match with the team came Monday in a 3-0 defeat against Sevilla that leaves the club two points above 18th-place Osasuna.
"The board of Granada CF has this morning removed the coach Juan Antonio Anquela," said a statement on the club's website.
"The club is now working to hire a new coach. Granada thanks Anquela for his involvement and work and wish him every success in his future career."
Anquela joined Granada over the summer from lower-division side Alcorcon.