Trey Zeigler scored a season-high 18 points and Pittsburgh crushed DePaul 93-55 on Saturday night for its fourth straight victory.
Lamar Patterson added 15 points, Steven Adams added nine points and a season-high 14 rebounds for the Panthers (17-4, 5-3 Big East), who climbed into a tie for third in the muddled Big East after dominating the reeling Blue Demons.
The 38-point margin of victory was the highest ever by Pitt in a Big East game, eclipsing a 36-point romp over West Virginia in 2003.
Brandon Young led DePaul (10-9, 1-5) with 13 points and Moses Morgan chipped in 11, but the Blue Demons were never in it while losing for the sixth time in seven games. DePaul shot just 27 percent (18 of 65) and was outrebounded 58-34 while suffering its worst loss in nearly two years.