Victor Oladipo scored 19 points, and seventh-ranked Indiana pounded Penn State, 72-49, at Assembly Hall.
Yogi Ferrell added 15 points and Will Sheehey scored 12 for the Hoosiers (17-2, 5-1 Big Ten), who have won two in a row since a 64-59 home loss to Wisconsin last Tuesday.
The Hoosiers won despite a career-low two points for Cody Zeller, who missed all four of his shots from the field.
"Cody did a lot of other things to impact the game and that's why he's such a great player," Oladipo said. "He might have a slow night today, but he played tremendous defense. He still had 10 deflections and rebounded the ball. He might be having a slow night on offense, but he's doing what it takes to win. Sure we've got to step it up a little bit, but when he plays like that we've just got to play together."
D.J. Newbill had 18 points and Jermaine Marshall added 12 for Penn State (8-11, 0-7), which suffered its seventh straight loss. The Nittany Lions fell to 0-4 in true road games this season. They have lost 14 in a row on the road since a 62-54 victory at Boston College on Nov. 30, 2011.
The Penn State perimeter defense couldn't stop the Hoosiers, who went 11-of-20 from beyond the 3-point arc.
"I didn't like our match-ups," Penn State coach Patrick Chambers said. "They are a very talented group and as a coach you have to do everything you can to try to help your team be successful. I felt like we mixed it up a lot, playing a lot of zone, but a little man and disguised the zone. We did a lot of different things and for a while it worked, but then talent takes over and they started making threes. Eleven threes is just too many because we are not a great three point shooting team."
Ferrell sank a 3-pointer and a jumper to cap a game-opening 7-0 burst. A layup from Jon Graham brought the Nittany Lions within seven points with 4 1/2 minutes left.
The Hoosiers surged with an ensuing 20-5 burst that lasted into the early stages of the second half. After holding a 33-19 lead at the break, Ferrell and Jordan Hulls opened the second half with consecutive 3-pointers. Oladipo's layup culminated the push for a 41-19 margin only a minute into the second half.
Oladipo's 3-pointer with under 14 minutes left created a 24-point difference, and the Hoosiers coasted to their fifth straight win over Penn State, which finished at 33 percent from the field.
Christian Watford had 10 points and nine rebounds for the Hoosiers, who own a 33-9 mark in the all-time series. That includes a 74-51 triumph at Penn State on Jan. 7 ... Penn State's last Big Ten road win came March 6, 2011 at Minnesota ... Indiana will host No. 13 Michigan State Sunday, while Penn State's next game is Saturday at home against No. 14 Ohio State.