Peyton Siva scored 17 points and No. 3 Louisville held South Florida to a season-low 27 percent shooting for an easy 64-38 victory on Saturday.
Center Gorgui Dieng added 12 points and 16 rebounds while forward Chane Behanan had 12 rebounds and seven points for the Cardinals (15-1, 3-0 Big East), who won their 10th in a row. Behanan played just five days after injuring his left ankle in practice and missing Wednesday's victory against Seton Hall.
Siva meanwhile bounced back from a 2-of-6 shooting effort against the Pirates to hit seven shots, including three 3-pointers. The Big East Conference preseason player of the year also surpassed 1,000 career points.
The Cardinals dominated the boards 49-24 including a 19-6 edge in offensive rebounds.
Victor Rudd came off the bench to score 10 points for South Florida (9-6, 0-3).