Kenny Boynton scored 20 points and Florida used a 31-6 run across the halves to rout LSU 74-52 on Saturday.
Patric Young had 14 points for the Gators (12-2, 2-0 SEC). Boynton's perimeter shooting and Young's interior play were instrumental in Florida controlling the offensive end.
The Tigers (9-4, 0-2) stuck around well into the first half before Florida broke a 19-all tie with a 10-1 run to end the half, punctuated by Scottie Wilbekin's jumper at the buzzer.
Anthony Hickey scored 15 points for LSU, who have lost 4 of 7 after starting the season with six-straight wins.