In one of the most high-profile rivalries in all of England, Manchester United gets set to host Liverpool at Old Trafford on Sunday as the Red Devils hope to extend their lead atop the Premier League table.
United and Liverpool are the two most successful clubs in the history of English soccer, combining for 37 league titles.
While United has dominated the Premier League era, Liverpool has fallen off of the radar. Under Sir Alex Ferguson, United has gone on to claim 12 league titles since 1993. Liverpool has not finished atop the league since 1990.
The disappointment has continued for Liverpool this term. Under new manager Brendan Rodgers, the Reds have failed to get back in contention for the title, coming into the weekend in eighth place on 31 points.
But in such a world-renowned match that has produced countless classic encounters, form goes out the window. Anything can happen.
United claimed a 2-1 victory at Anfield earlier this season, the difference being a dubious penalty decision.
Last season, the conflict between the two sides transcended the pitch as Luis Suarez racially abused Patrice Evra. The Uruguayan compounded the incident by failing to shake the hand of the United captain in the return match at Old Trafford.
"We have to concentrate on ourselves," Ferguson said in a press conference on Friday. "We respect every opponent and Luis Suarez is no different from any other good player we come up against."
A home win on Sunday would send United 10 points clear at the top of the table, placing additional pressure on Manchester City to keep pace. The Citizens round out a critical slate of Sunday fixtures with a trip to the Emirates to take on Arsenal, which occupies sixth place with 34 points.
On Saturday, third-place Tottenham will go for a fourth successive league win in crucial London derby. QPR snapped a three-game slide last time out with a shocking 1-0 defeat of Chelsea, and the Rangers will look to build upon that result when they welcome Spurs to Loftus Road.
Chelsea's loss to QPR saw the Blues drop to fourth place despite holding a game in hand over Tottenham. Before meeting up with Southampton on Wednesday, Rafa Benitez will lead his men to the Britannia to take on a Stoke City side that has stuttered a bit in Premier League play, claiming just one win from its last five outings.
Also on Saturday, Newcastle looks to snap a three-game losing skid when it heads to Carrow Road to face Norwich City, Aston Villa goes for its first win in its last four league matches when it hosts Southampton at Villa Park, Wigan hopes to climb out of the relegation zone with a positive result against Fulham at Craven Cottage, Everton looks to maintain its position in a European spot when it welcomes Swansea City to Goodison Park, West Bromwich hopes to avoid a third straight defeat when it faces Reading at the Madejski, and Sunderland tries to get back in the win column when it hosts West Ham at the Stadium of Light.