After claiming the Mexican Apertura title last season, Tijuana began its Clausura campaign on Sunday with a 2-1 win at Puebla.
First-half goals from Duvier Riascos and Cristian Pellerano handed Tijuana a two-goal advantage in the opening 41 minutes before Puebla pulled a goal back just before halftime through Roberto Juarez.
However, the visitors held on for the win over the second 45 minutes to collect three points and get off to a good start in the new season.
Tigres recorded the biggest win of the weekend as Emanuel Villa scored three times in the second half to lead his side to a 3-0 win over Jaguares, while Pachuca also notched a victory to open the season as second-half goals from Abraham Carreno and Hector Herrera helped the team down Atlante, 2-0.
Rubens Sambueza handed America a last-gasp 2-1 win over Monterrey as he converted a penalty kick deep in stoppage time, and Queretaro also got some late heroics in its 2-2 draw at Leon as Amaury Escoto scored the equalizer in the 90th minute.
San Luis and Santos finished in a 1-1 draw, Cruz Azul got two goals from Javier Penuelas in a 3-3 deadlock with Morelia on Friday, while the other two matches on Sunday also ended in draws.
Omar Bravo helped Atlas to a 1-1 stalemate at UNAM with his goal in the 79th minute, while Guadalajara and Toluca traded goals in the final 10 minutes of their 1-1 draw.