Markisha Wright tallied 20 points and eight rebounds in No. 5 Notre Dame's 128-55 rout of Saint Francis.
Kayla McBride added 19 points and four steals, while Michaela Mabrey chipped in 18 points and seven assists for the Fighting Irish (11-1), who have won six straight games since their lone loss to Baylor on Dec. 5.
Alexa Heyward had 13 points to lead the Red Flash (5-6).
Notre Dame netted 49 points off 33 Saint Francis turnovers.
It led 63-25 at the break, its largest halftime spread of the season.